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Posted on May 9, 2025

By Dr. Kulsoom Baloch

Understanding the Rhogam Shot in Pregnancy

By Dr. Kulsoom Baloch

Learn more about Dr. Baloch

Introduction

Pregnancy is a complex journey that involves many medical checks to protect both the mother and the baby. One such crucial intervention is the Rhogam shot. If you’ve been told you need it during pregnancy, this article will explain what Rhogam is, why it’s given, and how it helps ensure a safe pregnancy.

What Is the Rh Factor?

The Rh factor is a protein found on red blood cells. If your blood has the protein, you’re Rh- positive. If it doesn’t, you’re Rh-negative. Problems can arise during pregnancy when an Rh- negative mother carries an Rh-positive baby.

What Is Rh Incompatibility?

Rh incompatibility occurs when an Rh-negative mother is pregnant with an Rh-positive baby. The mother’s immune system may recognize the babys red blood cells as foreign and produce antibodies to attack them. This immune response can cause serious complications for the baby, especially in future pregnancies.

What Is the Rhogam Shot?

Rhogam is an injectable medication that prevents Rh-negative mothers from developing antibodies against Rh-positive blood. It works by neutralizing any fetal red blood cells in the mother’s bloodstream before her immune system reacts to them.

When Is Rhogam Given?

  • Around the 28th week of pregnancy
  • Within 72 hours after delivery if the baby is Rh-positive
  • After any event where fetal blood might mix with maternal blood (amniocentesis, miscarriage, abdominal trauma, etc.)

Why Is Rhogam Important?

Without Rhogam, an Rh-negative mother may become sensitized, meaning her body produces antibodies that can attack an Rh-positive fetus in future pregnancies. This can lead to hemolytic disease of the newborn (HDN), causing anemia, jaundice, and even fetal death.

Is Rhogam Safe?

Yes. Rhogam has been used for decades and is considered very safe. It does not harm the mother or baby and does not affect future fertility.

How Do I Know If I Need Rhogam?

A simple blood test early in pregnancy will determine your Rh status. If you’re Rh-negative, your doctor will discuss whether you need Rhogam based on your partner’s Rh type or baby’s Rh factor.

Rhogam and Surrogacy

In surrogacy arrangements, Rh factor testing is equally important. Surrogates who are Rh- negative may also require Rhogam to ensure a healthy pregnancy and safe delivery.

Conclusion

The Rhogam shot is a small but vital step in preventing serious complications related to Rh incompatibility. If you’re Rh-negative, be sure to ask your healthcare provider about Rhogam and how it fits into your prenatal care. At Surrogacy4All, we ensure that both intended parents and surrogates receive the medical support they need.

Dr. Kulsoom Baloch
MBBS, MPH â€“ kulsoom@indianeggdonors.com

Dr. Kulsoom Baloch is a dedicated donor coordinator at Egg Donors, leveraging her extensive background in medicine and public health. She holds an MBBS from Ziauddin University, Pakistan, and an MPH from Hofstra University, New York. With three years of clinical experience at prominent hospitals in Karachi, Pakistan, Dr. Baloch has honed her skills in patient care and medical research.