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IVF Treatment Decisions

Course / IVF Treatment Decisions

Introduction & Additional Resources

When pursuing gestational surrogacy, IVF treatment decisions play a crucial role in determining the success of embryo creation and transfer. Every choice—from how long to culture embryos, to whether to perform genetic testing, to the number of embryos transferred—can significantly influence pregnancy outcomes.

At Surrogacy4All, our medical team collaborates with top fertility centers to design treatment protocols optimized for each intended parent’s needs. This course explains the core decisions that impact IVF success in surrogacy and provides evidence-based insights into each stage of the process.

For further reading, intended parents and surrogates can refer to our educational resources on:

  • [Embryo Development and Grading]

  • [PGT-A and Genetic Testing]

  • [Optimizing Embryo Transfer Success]

Growing Embryos to Blastocyst Stage

Embryo culture duration is one of the most significant IVF decisions. Embryos can be transferred or frozen at either the cleavage stage (day 3) or the blastocyst stage (day 5–6).

Growing embryos to the blastocyst stage allows embryologists to:

  • Identify embryos with better developmental potential, improving the likelihood of implantation.

  • Facilitate more accurate selection for transfer or genetic testing.

  • Synchronize with the gestational carrier’s uterine lining for optimal implantation timing.

However, not all embryos will survive to the blastocyst stage, which can reduce the total number available for transfer or freezing. Clinics with highly skilled embryologists and optimal lab conditions—like those partnered with Surrogacy4All—achieve higher blastocyst development rates, minimizing this risk.

Expert Insight:
For most surrogacy cases, transferring a day-5 blastocyst provides the best balance of implantation potential and genetic normality, particularly when preimplantation genetic testing (PGT-A) is also planned.

Pre-implantation Genetic Testing of Embryos for Aneuploidy (PGT-A)

Preimplantation Genetic Testing for Aneuploidy (PGT-A) is now a standard component of many IVF cycles, especially in gestational surrogacy. This test evaluates embryos for chromosomal abnormalities that can lead to implantation failure, miscarriage, or genetic disorders.

Benefits of PGT-A:

  • Improved implantation rates: Selecting chromosomally normal (euploid) embryos increases the chance of pregnancy.

  • Reduced miscarriage risk: Abnormal embryos are less likely to implant or may result in early pregnancy loss.

  • Supports single embryo transfer: Confidently transferring one healthy embryo minimizes the chance of twins.

  • Optimized use of embryos: Helps prioritize which embryos to transfer or freeze.

PGT-A is especially useful for:

  • Intended parents over age 35.

  • Couples with previous IVF failures or miscarriages.

  • Donor egg or sperm cycles where genetic accuracy is essential for surrogacy efficiency.

Surrogacy4All partners exclusively with labs experienced in advanced biopsy and genetic screening techniques to ensure accuracy and safety.

Single Embryo Transfer

Single Embryo Transfer (SET) is now widely recommended as the standard of care in gestational surrogacy. While transferring multiple embryos may appear to increase the chance of success, it significantly raises the risk of multiple pregnancies, which can endanger both the surrogate and the babies.

Why SET Is the Preferred Choice:

  • Higher safety: Reduces complications such as preterm delivery, gestational hypertension, and cesarean birth.

  • Comparable success: When using high-quality, genetically screened blastocysts, SET provides similar live birth rates to double transfers.

  • Simplified logistics: Reduces risk, stress, and medical complexity for the gestational carrier.

At Surrogacy4All, over 90% of all embryo transfers are performed as single euploid transfers, following best practices from the American Society for Reproductive Medicine (ASRM).

Expert Insight:
Transferring one healthy embryo offers the best balance between success rate and maternal safety — ensuring the surrogate’s well-being and the best possible start for the child.

Doctor Doing the Transfer

The final stage of the IVF process—the embryo transfer—is delicate and technically complex. Success can depend as much on the skill of the physician performing the procedure as on embryo quality itself.

What Defines a High-Quality Transfer:

  • Proper catheter placement: The embryo must be placed at the optimal depth within the uterine cavity, avoiding trauma to the lining.

  • Smooth transfer technique: Gentle handling, correct fluid volume, and minimal uterine contractions are essential.

  • Use of ultrasound guidance: Allows visualization of the catheter tip for precise embryo placement.

Many clinics assign embryo transfers to their most experienced reproductive endocrinologists or senior embryologists.

At Surrogacy4All, we ensure that every partner clinic performing surrogacy transfers uses experienced transfer specialists with a proven track record of success.

Pro Tip:
Ask your clinic about the individual transfer success rates of the physicians involved, not just the overall clinic rate. The best centers track and report this internally as part of their quality assurance.